Bsense Announces Positive Topline Proof-of-Concept Preclinical Data that Supports the Development in Additional Sensory Hyperexcitability Related Disorders – GlobeNewswire
NESS ZIONA, Israel, Dec. 06, 2021 (GLOBE NEWSWIRE) — Bsense Bio Therapeutics Ltd., a FutuRx portfolio biopharmaceutical company dedicated to developing novel therapeutics for treatment of sensory hyperexcitability disorders, today announced positive topline data in a comparative preclinical study of its leading compound BSEN627 with pregabalin in chronic pain. The data indicate that treatment with BSEN627 significantly alleviates chronic pain, potentially without any major…….
NESS ZIONA, Israel, Dec. 06, 2021 (GLOBE NEWSWIRE) — Bsense Bio Therapeutics Ltd., a FutuRx portfolio biopharmaceutical company dedicated to developing novel therapeutics for treatment of sensory hyperexcitability disorders, today announced positive topline data in a comparative preclinical study of its leading compound BSEN627 with pregabalin in chronic pain. The data indicate that treatment with BSEN627 significantly alleviates chronic pain, potentially without any major related side effects, supporting its lead determination. Moreover, the data provide support in broadening its indication to additional sensory hyperexcitability related disorders.
The comparative study was designed to investigate anti-nociceptive efficacy and safety of BSEN627 vs pregabalin in the Spared Nerve Injury (SNI) pain rat model. Results from the study demonstrate that BSEN627 alleviated chronic pain supporting plans for further clinical development. Additional key findings from the study include:
- BSEN627 significantly alleviated the mechanical allodynia pain for up to 32 hours after a single administration
- BSEN627demonstrated comparable pain relief (mechanical) at significantly lower exposure levels compared to Pregabalin’s maximal efficacious human dose
- BSEN627 demonstrated a PK/PD profile, which supports the translation of in-vitro to in-vivo
- BSEN627 demonstrated a significant therapeutic window from target related safety concerns, while Pregabalin showed significant impairment
“Results from this study are very encouraging and demonstrate the potential for superior efficacy and safety in the treatment of chronic pain,” said Haim Belinson, Chief Scientific Officer of Bsense. “In addition, these results indicate that our novel mode of action (MOA) translates from in-vitro to in-vivo in a predictive manner. We look forward to continuing development of the Bsense dual ion-channel modulator technology in chronic pain, and exploring other potential indications such as tinnitus, pruritus and other pain indications in need of better standard of care.” Dr. Belinson continued, “We are very pleased that progress follows the work of Dr. David Julius, who has been recently awarded the Nobel Prize in Physiology or Medicine for his discovery of TRPV1 as the primer of the biology of senses, and optimistic for continued success along this development pathway.” Our current data supports our vision to continue development of the Bsense dual ion-channel modulator technology” added Belinson. “We envision these orally available, non-addictive treatments to be fitting for orphan and non-orphan sensory hyperexcitability related indications such as Tinnitus, Pruritus and Pain that are lacking efficacious and safe therapies” he concluded,
Dr. Kinneret Livant Savitzky, CEO of the FutuRx bio incubator added, “We are excited by the impressive efficacy and safety data from the dual ion-channel modulator technology presented by our portfolio company Bsense Bio Therapeutics. This clear demonstration of their ability to quell sensory neuron hyperexcitability offers a new hope for patients suffering from dire conditions such as neuropathic and chronic pain, …….
